The US Food and Drug Administration granted the GRAS (Generally Recognized as Safe) status for Reb A in food products in December 2008. Extensive studies have shown that Reb A does not affect blood glucose or insulin levels. Studies have shown that Reb A is safe for diabetics. Reb A has also been shown to be non-mutagenic and does not affect the GI tract at normal levels of use, providing a very satisfying and natural sweetening alternative to sugar.